2 edition of Scolnick Tumor Viruses & Differentiation found in the catalog.
Scolnick Tumor Viruses & Differentiation
January 11, 1984
by John Wiley & Sons Inc
Written in English
|The Physical Object|
|Number of Pages||478|
Dr. Edward Scolnick Oral History Download the PDF: Scolnick_Edward_Oral_History_ (PDF MB) National Cancer Institute Oral History Project Interview with Edward Scolnick, M.D. conducted on J , by Gretchen A. Case at Dr. Scolnick's o. The growth-promoting and/or differentiation-blocking activities of Kirsten (Ki-MSV) or Harvey murine sarcoma virus (Ha7–MSV) on various types of cells in vitro are well documented1–8. Here we.
Tumor grade is the description of a tumor based on how abnormal the tumor cells and the tumor tissue look under a microscope. It is an indicator of how quickly a tumor is likely to grow and spread. If the cells of the tumor and the organization of the tumor’s tissue are close to those of normal cells and tissue, the tumor is called “well. Scolnick E.M., Rands E., Williams D., Parks W.P.: Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus. J. Virol. 12, – (). PubMed Google Scholar.
tial for differentiation, virus Scolnick, E. M.: Rapid leukemia When Charlotte Friend showed that explants of transplantable subcutaneous tumors, originated from virus-induced murine. Tumor viruses Viruses associated with tumors can be classified in two broad categories depending on the nucleic acid in the viral genome and the type of strategy to induce malignant transformation. RNA viruses The ribonucleic acid (RNA) tumor viruses are retroviruses. When they infect cells, the viral RNA is copied into deoxyribonucleic acid (DNA) by.
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Troxler DH, Lowy D, Howk R, Young H, Scolnick EM. Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus.
Proc Natl Acad Sci U S A. Oct; 74 (10)– [PMC free article] Temin HM. On the origin of RNA tumor viruses. Annu Rev Genet. Get this from a library. Tumor viruses and differentiation: proceedings of the CETUS-UCLA Symposium held at Squaw Valley, California, March[Edward M Scolnick; Arnold J Levine; Cetus Corporation.; University of California, Los Angeles.;].
Greenberger JS. Phenotypically distinct target cells for murine sarcoma virus and murine leukemia virus marrow transformation in vitro.
J Natl Cancer Inst. Feb; 62 (2)– Hankins WD, Scolnick EM. Harvey and Kirsten sarcoma viruses promote the growth and differentiation of erythroid precursor cells in vitro.
by: Abelson murine leukemia virus (A-MuLV) and Harvey murine sarcoma virus (Ha-MSV) are retroviruses carrying unrelated onc genes.
However, both of these viruses are capable of stimulating the growth and differentiation of erythroid precursor cells; the target cells for both appear at the same time during fetal development and follow a similar pattern throughout by: Hankins WD, Scolnick EM.
Harvey and Kirsten sarcoma viruses promote the growth and differentiation of erythroid precursor cells in vitro. Cell. Oct; 26 (1 Pt 1)– Hagag N, Halegoua S, Viola M. Inhibition of growth factor-induced differentiation of PC12 cells Cited by: J.
Nat. Cancer Inst. 24, Nooter, K. and Ghio, R. Hormone-independent in vitro eryth roid colony formation by bone marrow cells from Rauscher virus infected mice.
Nat. Cancer Inst. 55, Nooter, K. and Bentvelzen, P. In vitro transformation of murine erythroid cells by Rauscher leukemia virus. Cancer Letters 1. T~~~~ Viruses and differed ti~~i~~ UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 5 Edited by EM Scolnick and A.
Levine Alan R. Liss; New York, pages. f This book is a compilation of papers from a sym- posium held in March It includes presenta. Viruses are major causes of cancer in animals, but the extent of their role in human cancer is unknown.
Studies utilizing molecular hybridization have contributed much to the understanding of tumor virus gene expression and have provided the methodology and nucleic acid reagents so that human tumors can be analyzed for viral genetic information.
The factor has allowed T cells to be cloned into various classes. Several groups of investigators are attempting to develop ways to treat human tumors with such differentiated T cell popula tions. Studies on the mouse mammary tumor virus (Bittner) by Parks, Scolnick, and HOWARD H. YOUNG revealed its utility for investigating steroid hormone action.
Several viruses, known as oncogenic viruses, are associated with cancer. These viruses can cause mutations, affect gene expression, or lead to chronic inflammation.
Harvey and Kirsten sarcoma viruses promote the growth and differentiation of erythroid precursor cells in vitro Author links open overlay panel Hankins Edward M. Scolnick Show more. Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses.
Skip to main content Environmental Tumor Promoters W. & Scolnick, E. Cancer. Yagi MJ. Cultivation and characterization of BALB-cfC3H mammary tumor cell lines.
J Natl Cancer Inst. Dec; 51 (6)– Parks WP, Scolnick EM. Murine mammary tumor cell clones with varying degrees of virus expression. Virology. Sep; 55 (1)– EBNER KE, HOOVER CR, HAGEMAN EC, LARSON BL.
Author(s): Scolnick,Edward M; Levine,Arnold J(Arnold Jay),; CETUS-UCLA Symposium,( Squaw Valley, Calif.) Title(s): Tumor viruses and differentiation. An ever-increasing amount of work is being published on the influence of specific RNA tumour viruses on erythroid differentiation in the mouse [1–10].
This review will be restricted to discussion of the action of those C-type viruses which influence erythropoiesis in the adult mouse [1–3, 9, 10] and moreover to viruses which have been used.
DNA TUMOR VIRUSES INVOLVED IN HUMAN CANCERS. The first DNA tumor viruses to be discovered were rabbit fibroma virus and Shope papilloma virus, both discovered by Richard Shope in the s.
Papillomas are benign growths, such as warts, of epithelial cells. They were discovered by making a filtered extract of a tumor from a wild rabbit and. The oncogenes of Harvey and Kirsten murine sarcoma viruses (v-rasH and v-rasK) and their cellular homologues (c-rasH and c-rasK) constitute two members of the ras gene family.
Each functional. SEVERAL RNA tumour viruses including the Friend1, Rauscher2 and Kirsten (MLV-Ki)3 strains cause erythroid leukaemia in mice. These agents do not transform cells in vitro, but provide a helper.
Differentiation and Anaplasia well differentiated/poorly differentiated anaplasia = (Fig ) carcinoma in situ (figure not in book) 2. Rates of Growth (Figure not in book) doubling time of tumor cells* (* indicates material not in text) growth fraction of tumor cells* tumor cell heterogeneity* Oncogenic DNA virus binds RB: TP53 Gene.
Fusco, A. Pinto, D. Tramontano, G. Tajana, G. Vecchio and N. Tsuchida, Block in the expression of differentiation markers of rat thyroid epithelial cells by transformation with Kirsten murine sarcoma virus, Cancer Res. PubMed Google Scholar. ISBN: OCLC Number: Description: pages: illustrations ; 25 cm: Contents: The Nature of the host range restriction of SV40 and polyoma viruses in embryonal carcinoma cells/A.J.
Levine --The Immune response to C-Type viruses and its potential role in leukemogenesis/J.N. Ihle, L. Enjuanes, J.C. Lee, J.
Keller --Mammary tumor.Tumor viruses and differentiation: proceedings of the CETUS-UCLA Symposium held at Squaw Valley, California, MarchTumour-associated mutant p53 drives the Warburg effect Tumour suppressor genes, the cell cycle and cancer.In the 34 years since the isolation of Epstein-Barr virus there has been an accumulation of evidence linking some important human cancers and viruses.
This book describes the molecular biology and pathogenesis of these viruses, including those only recently associated with human cancers. It provides an up-to-date account of the progress in our knowledge of the virus/host interactions which.